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ChiWriter is a WYSIWYG scientific text editor for DOS. Created by Cay Horstmann in 1986, it was one of the first that could write mathematical formulas on common PC computers.
Lighthouse Design Ltd Productivity Applications is an application suite of programs for NeXT computers.
Mathcad is an easy to use graphical calculation program targeted at engineering professionals. It supports a wide variety of mathematical functions. There were versions for DOS, Macintosh, and Windows.
Mathematica, from Wolfram Research, Inc., is a mathematical and scientific application to formulate complex equations. and Mathworks MatLab.
SPSS/PC+ is high end statistics package that supports organizing, analyzing, and graphing data.
Statpro is a comprehensive statistics system for Apple II, and later IBM PC, computers. It is written using the UCSD P-System.